Alterations in cerebrospinal fluid pressure (intracranial pressure) may be studied by one of two methods: first, lumbar puncture with the needle connected with a pressure apparatus and continuous readings for several hours, or repeated punctures with pressure readings; second, in the case of patients with large defects in the skull, the use of a mechanical arrangement to record pressure changes on a tambour. In this study the first method has been used. The immediate effects of spinal fluid drainage, of fluids and of drugs have been studied by lumbar puncture with a manometer in situ for two or more hours. In some instances late effects have been studied by repeated punctures.
Investigation of the type described should be carried out with great care, for the possibilities of error are manifold. Both in the human subject and in the experimental animal there are several avenues of error. These may be tabulated
GURDJIAN ES, WEBSTER JE, SPRUNK CJ. STUDIES OF THE SPINAL FLUID IN CASES OF INJURY TO THE HEADEFFECTS OF DRAINAGE, ISOTONIC FLUIDS, MORPHINE AND SOLUBLE PHENOBARBITAL U. S. P. ON CEREBROSPINAL FLUID PRESSURE. Arch NeurPsych. 1939;42(1):92-111. doi:10.1001/archneurpsyc.1939.02270190100006