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August 1939

INFLUENCE OF FEAR, PHARMACOLOGIC ACTION AND CONVULSION IN METRAZOL THERAPY

Author Affiliations

CHICAGO

Prom the Psychiatric Institute (Dr. H. Douglas Singer, Director) of the Research and Educational Hospital, the University of Illinois College of Medicine.

Arch NeurPsych. 1939;42(2):233-236. doi:10.1001/archneurpsyc.1939.02270200053005
Abstract

Three main factors, either singly or in combination, have been held responsible for the therapeutic results obtained with metrazol treatment of psychotic patients: (1) the convulsion, (2) the pharmacologic effect of the drug and (3) the fear reaction. In the present study it was attempted to isolate the emotional and pharmacologic reactions and to investigate their effects on the blood pressure, pulse, respiration, leukocytes and various chemical constituents of the blood.

MATERIAL AND METHOD  Seventeen patients (12 men and 5 women) who were receiving a course of metrazol treatment were studied. Their ages ranged from 15 to 44; the average age was 28.3. In 9 of the cases the disease was classified as schizophrenia; in 6, as manic-depressive psychosis; in 1, as a primary behavior disorder, and in 1, as a traumatic psychosis.Six of the patients, during the second, third or fourth week of treatment, were given a dose

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