Standardized estrogenic preparations have been in use for the past ten years.1 There is general agreement that these substances are effective in the treatment of disorders of the climacteric, which are evidenced by such symptoms as hot flashes, dizziness, vasomotor imbalance and headache. Gynecologists are agreed that the majority of patients suffering from these menopausal symptoms are relieved, but admit that a few patients benefit little from treatment and that there is no adequate explanation of this failure. There is less agreement among psychiatrists as to the beneficial results of estrogenic therapy for involutional melancholia. Some workers2 have been enthusiastic in recommending such treatment, while others3 have reported results which seem to indicate that therapy of this type is not effective in cases of this disorder.
During the early years in which estrogenic substances were given to patients with involutional melancholia, the dose reported seems now, in
DYNES JB. ESTROGENIC THERAPY OF INVOLUTIONAL MELANCHOLIA. Arch NeurPsych. 1939;42(2):248-259. doi:10.1001/archneurpsyc.1939.02270200068007