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September 1939

PROTECTIVE EFFECT OF CHOLESTEROL IN EXPERIMENTAL EPILEPSY

Author Affiliations

SAN FRANCISCO

From the Departments of Surgery (Dr. Aird) and Pharmacology (Dr. Gurchot) of the University of California Medical School.

Arch NeurPsych. 1939;42(3):491-506. doi:10.1001/archneurpsyc.1939.02270210129006
Abstract

Attention has turned in recent years to an explanation of the cause of epilepsy in terms of biochemical and physiologic dysfunction.1 An excellent review of the research along these lines is provided in the monograph on epilepsy by Lennox and Cobb.2

The facts that fasting and a high fat, low carbohydrate diet are known to benefit patients with epilepsy3 and that these procedures bring about changes in the concentration of blood lipids4 have led to an investigation of the vital lipids in epilepsy.

Cholesterol, especially, has been studied. De Crinis5 and Targowla, Badonnel and Berman6 reported hypercholesteremia in patients with 491 epilepsy. Albertoni and Borgatti7 also found hypercholesteremia in dogs during and after the induction of convulsions by the use of 20 per cent camphor in oil and direct electrical stimulation of the rolandic area. They concluded that the rise in cholesterol is

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