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The aim of this book, dedicated to the memory of von Lenhossék, is to show that "the normal neuron is topographically identical with the pathologic neuron" and that it "reacts differently to endogenous and to exogenous factors." An introductory chapter discusses in general the relation of the neuron theory to neuropathology and defines briefly the endogenous and exogenous types of reaction of the neuron to various pathologic agencies. In the endogenous reaction the ectodermal elements are primarily affected; in the exogenous, the mesodermal, with consecutive involvement of the neurons.
The endogenous reaction is discussed in the first part (pages 43 to 212). Hereditary diseases fall into this class. They are frequently circumscribed, and are then characterized by the disturbance (1) of a well defined system; (2) of a distinct segment of the neural tube (e. g., rhombencephalon or telencephalon), and (3) of exclusively neuroectodermal elements. This has been called by
Histopathologie des Neurons.. Arch NeurPsych. 1939;42(3):591-592. doi:10.1001/archneurpsyc.1939.02270210229015