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October 1939

TREATMENT OF SCHIZOPHRENIA WITH GLANDULAR EXTRACTS

Author Affiliations

SAN FRANCISCO

Arch NeurPsych. 1939;42(4):644-651. doi:10.1001/archneurpsyc.1939.02270220060002
Abstract

I have previously proved by means of experiments that schizophrenia is regularly accompanied by a disturbance in metabolic energy. The results, already published,1 were based on the investigation of 277 cases, in most of which more than one examination was made. The disturbance in the rate of oxygen consumption shows itself in alteration not only of the basal metabolic rate, a factor I wish particularly to stress, but also—and this is of great importance for further research— of the specific dynamic action of protein.

By the specific dynamic action of protein I mean, in accordance with Rubner's investigations, the rise in the consumption of oxygen simultaneously with the increase in the production of carbon dioxide after the ingestion of protein. The highest point is reached one or one and one-half hours after ingestion. In normal persons, when they are given 200 Gm. of meat the specific dynamic action of

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