[Skip to Content]
[Skip to Content Landing]
Other
October 1939

MODE OF ACTION OF BRILLIANT VITAL RED IN EPILEPSY

Author Affiliations

SAN FRANCISCO

From the Department of Surgery, University of California Medical School.

Arch NeurPsych. 1939;42(4):700-723. doi:10.1001/archneurpsyc.1939.02270220116007
Abstract

In a previous paper1 evidence was presented which tends to support the hypothesis that epilepsy is closely related to a disturbance in the metabolism of the vital lipids cholesterol and lecithin. The biochemical effects of these lipids and the known facts concerning epilepsy which contribute to this conception were reviewed. Parenteral injections of cholesterol were found to have a protective effect on white mice with experimental epilepsy induced by cocaine hydrochloride. Furthermore, it was observed that the convulsive effects were later in onset in the mice protected by cholesterol than they were in the groups used as controls. This was interpreted as indicating a delayed absorption of the convulsive agent. The protective effect, likewise, was explained on this basis. The results of the study were thus interpreted as consistent with the theory that the vital lipids play a significant role in the permeability of cell membranes and, through this

×