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November 1939

RHYTHMIC VARIATION OF RESPIRATORY EXCURSION WITH BILATERAL INJURY OF CORTICAL EFFERENT FIBERS

Author Affiliations

BALTIMORE

From the Subdepartment of Neurology, the Johns Hopkins University, and the Medical Division of the Baltimore City Hospitals.

Arch NeurPsych. 1939;42(5):862-871. doi:10.1001/archneurpsyc.1939.02270230084006
Abstract

The majority of studies of respiration have been concerned with the respiratory center in the medulla and the factors which influence its activity. Little attention has been given to the control of higher centers over this lower reflex mechanism. Recently, we recorded tremulousness of respiratory movement in cases of palatal myoclonus (Langworthy and Grimmer1). In this syndrome there is degeneration of the central tegmental fasciculus, the inferior olivary nucleus and often the dentate nucleus of the cerebellum.

In studying patients at the Baltimore City Hospitals we noticed that many with injury of the motor cortex on one or both sides showed a rhythmic variation of respiratory excursions. This was similar to Cheyne-Stokes respiration, especially in the more marked cases. These patients were not unconscious, nor did they have manifest circulatory inadequacy. Indeed, the respiratory changes persisted for weeks or months. In this paper we shall consider cases in which

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