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December 1939

DEMENTIA PARALYTICAEFFECT OF CONTINUOUS INTENSIVE THERAPY WITH TRYPARSAMIDE AND BISMUTH ON CEREBROSPINAL SEROLOGIC REACTIONS AND FREQUENCY OF RELAPSE

Author Affiliations

ST. Joseph, MO.

Arch NeurPsych. 1939;42(6):1068-1075. doi:10.1001/archneurpsyc.1939.02270240106007
Abstract

Frequent relapses in cases of dementia paralytica having followed modern methods of treatment, it was decided to apply intensive and continuous treatment with tryparsamide and bismuth alone, or after malaria when feasible, until reversal of the serologic state of the cerebrospinal fluid occurred. Certain clinical evidences and opinions which lend justification to this procedure have presented themselves. I am aware of no other series in which treatment has been intensive and continuous until the Wassermann reactions of the spinal fluid became negative or until death supervened.

MATERIAL  Thirty-eight patients with dementia paralytica were treated from April 4, 1930 to Sept. 13, 1938; all were women. The following were common factors in treatment: First, tryparsamide was administered in doses of 3 Gm. continuously each week, except for two weeks twice each year preceding examinations of the blood and spinal fluid; second, thio-bismol, in doses of 0.02 Gm., was given twice a

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