We shall not discuss the advantages or disadvantages of the metrazol treatment in this paper, but report 2 cases of deaths which in our opinion were unusual and unexpected.
The method of administration is well known and will not be discussed here. Briefly, we used the standard 10 per cent solution of metrazol intravenously on alternate days, three times a week. Breakfast was omitted on treatment mornings, and in its place we gave 300 cc. of a 40 per cent solution of sucrose. The initial dose of metrazol was usually between 2 and 4 cc., depending on the body weight, and this was gradually increased by about 0.3 to 0.5 cc., in order to obtain a grand mal seizure with each injection.
REPORT OF CASES
—P. H., a white man aged 56, married, was admitted to the Columbus State Hospital on Aug. 12, 1938, in a rather poorly
Michael N, Wittenbrook J. METRAZOL TREATMENT OF THE PSYCHOSES Report of Two Deaths. Arch NeurPsych. 1940;43(3):560-563. doi:10.1001/archneurpsyc.1940.02280030134011