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April 1940

METRAZOL CONVULSIONSCHANGES IN OXYGEN, CARBON DIOXIDE AND SUGAR CONTENTS OF ARTERIAL AND OF INTERNAL JUGULAR VENOUS BLOOD

Author Affiliations

BOSTON

From the Division of Psychiatric Research, Boston State Hospital.

Arch NeurPsych. 1940;43(4):682-692. doi:10.1001/archneurpsyc.1940.02280040069004
Abstract

That there is obvious cerebral hypoxia during the metrazol convulsion, as indicated by a subnormal oxygen content of the arterial blood, has been demonstrated by Himwich and his associates.1 Since only a single sample of blood from either an artery or the internal jugular vein was obtained during each convulsion, no further conclusions concerning the oxygen metabolism of the brain could be made.

The present study is concerned with changes in oxygen, carbon dioxide and sugar in blood from the basilic vein and particularly from the internal jugular vein and brachial artery obtained before, during the various stages of and after the metrazol convulsion. Passive and cooperative subjects with dementia praecox were utilized. The experiments were carried out in the morning, breakfast being withheld from all subjects. The gas determinations were made by the method of Van Slyke and the sugar determinations by the method of Folin and Wu.

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