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July 1940

The Content of Cells and Proteins in the Normal Cerebrospinal Fluid.

Arch NeurPsych. 1940;44(1):241. doi:10.1001/archneurpsyc.1940.02280070249020

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Abstract

The author attempts to determine, from a critical examination of the literature and the results of his own extensive experience, what is the normal content of the cerebrospinal fluid in cells and protein, which he considers the two most important constituents, since increase in protein may result in purely secondary alterations in the electrolytes. Neel prefers the Fuchs-Rosenthal counting chamber, but believes it often advisable to have one with a larger capacity. For determination of the total protein he uses Bisgaard's technic for the Roberts-Stalnïkov-Brandberg method, and for globulin, the Bisgaard modification of the Ross-Jones method. For the former method he claims an exactitude of 2.7 per cent when the quantity of protein is small; for larger quantities the Kjeldahl method must be used. Neel claims also that when the two methods are used it is possible usually to dispense with the Lange and similar colloidal reactions. He criticizes former

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