Although the use of metrazol in the treatment of some psychoses and psychoneuroses is of comparatively recent origin, it has already proved of definite value. The literature on its advantages is voluminous and, although metrazol used in convulsive doses theoretically should be associated with a certain degree of danger to life, there have been very few deaths reported from its use. Von Angyal and Gyárfás1 appear to have published the first report of death from metrazol (see table). Subsequent deaths have been mentioned in articles by Stähli and Briner,2 Hayman and Brody,3 Fellows and Koenig4 and Hassin.5 Neuropathologic studies on animal experiments have been reported by Stender,6 Reitmann7 and Liebert and Weil.8 The characteristic observations in the brains of animals which died after injections of metrazol were subarachnoid and intracerebral hemorrhages similar to those in the human patient studied by us.
Roback HN, Miller CW. SUBARACHNOID AND INTRACRANIAL HEMORRHAGES DUE TO METRAZOL. Arch NeurPsych. 1940;44(3):627-635. doi:10.1001/archneurpsyc.1940.02280090146011