In Rocky Mountain spotted fever, cerebral disturbances are as common as they are in the classic spotted (typhus) fever, namely, headache, restlessness, hyperesthesia, lethargy, delirium, occasional convulsions and muscular rigidity.1a The histologic neural changes in the brains of patients dying of typhus fever have been extensively studied, especially abroad, and are classified as meningoencephalitis. In reports of cases of Rocky Mountain spotted fever in man the changes in the central nervous system are only casually referred to, but they have been studied a great deal in animals. Because of the clinical similarity between these two morbid entities, which may be so great that one is occasionally mistaken clinically for the other,1b the pathologic features of the two diseases also would be expected to be similar. A histopathologic study of the brain of a victim of Rocky Mountain spotted fever, which was placed at my disposal by Dr. M.
Hassin GB. CEREBRAL CHANGES IN ROCKY MOUNTAIN SPOTTED FEVER. Arch NeurPsych. 1940;44(6):1290-1295. doi:10.1001/archneurpsyc.1940.02280120137013