The recognition of neurologic signs and symptoms during the course of Hodgkin's disease has called to our attention the need for more careful correlation between the clinical and the pathologic aspects of all cases of lymphogranulomatosis. Ginsburg1 called attention to the paucity of information in textbooks of neurology regarding the involvement of the central nervous system in Hodgkin's disease. There are, however, numerous reports in the literature to indicate that such involvement occurs more frequently than is recognized generally.
In not an inconsiderable percentage of cases of Hodgkin's disease there is as the initial, and occasionally only, manifestation evidence of involvement of the central or peripheral nervous system. This observation is of diagnostic importance. The first of the 2 case reports in this paper illustrates the necessity of a careful evaluation of widely distributed neurologic signs and symptoms, which may be the earliest indication of Hodgkin's disease.
WINKELMAN NW, MOORE MT. LYMPHOGRANULOMATOSIS (HODGKIN'S DISEASE) OF THE NERVOUS SYSTEM. Arch NeurPsych. 1941;45(2):304-318. doi:10.1001/archneurpsyc.1941.02280140114012