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June 1941

PERIPHERAL BLOOD FLOW IN SCHIZOPHRENIA AND OTHER ABNORMAL MENTAL STATESA PLETHYSMOGRAPHIC STUDY

Author Affiliations

CINCINNATI

From the May Institute for Medical Research of the Jewish Hospital, and the Longview State Hospital.

Arch NeurPsych. 1941;45(6):973-979. doi:10.1001/archneurpsyc.1941.02280180085005
Abstract

The peripheral circulation in schizophrenia has recently been the subject of a number of investigations. Olkon,1 in a study of the character of the cutaneous capillaries in a large series of schizophrenic subjects, concluded that there were a definite deficiency and typical morphologic abnormalities in this portion of the vascular bed, the severity of the disease being related to the degree of derangement. Freeman,2 investigating circulation time in normal and in schizophrenic subjects, found that the schizophrenic group was characterized by an abnormally slow and highly variable rate of blood flow. On the other hand, Gottlieb3 presented evidence that the circulation time was normal in this disease. Other studies on schizophrenic subjects have indicated a certain degree of dysfunction of the autonomic nervous system, as suggested by abnormal responses to exposure to cold and hot baths,4 to warm air5 and to the intravenous administration of

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