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July 1941

Notes on Diffuse Sclerosis, Diffuse Gliomatosis and Diffuse Glioblastomatosis of the Brain, with a Report of Two Cases.

Arch NeurPsych. 1941;46(1):195. doi:10.1001/archneurpsyc.1941.02280190205020

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This brief monograph consists of the reports of 2 cases. The first case is one of a true neoplastic tumor (diffuse glioblastoma), the blastomatous growth constituting the primary phase and the demyelination and the axonal lesions the secondary phase in the process. The localization of the tumor and its spread along blood vessels and fiber tracts are unusual.

The second case is one in which the demyelination is primary and the glial overgrowth secondary, possibly representing an intermediate process between gliosis and the formation of a diffuse astrocytoma.

Several similar cases from the literature are cited and reviewed briefly. The not infrequent occurrence of diffuse gliomas with corresponding demyelination is pointed out.