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October 1942

CENTRAL NERVOUS SYSTEM IN VITAMIN E-DEFICIENT RATS

Author Affiliations

NEW YORK

From the Departments of Neurology and Pathology, Columbia University College of Physicians and Surgeons.

Arch NeurPsych. 1942;48(4):538-551. doi:10.1001/archneurpsyc.1942.02290100038004
Abstract

During the past two years there have appeared numerous articles1 dealing with the treatment of amyotrophic lateral sclerosis and other chronic degenerative diseases of the central nervous system with vitamin E in crude or purified form. These studies have been instigated by the currently accepted view that chronic vitamin E deficiency in rats brings about neurologic lesions more or less comparable to those found in human diseases. Since this is contrary to experience in this laboratory, we have undertaken anew a study of the question.

REVIEW OF LITERATURE  The first reference to possible alteration of neuromuscular function in cases of vitamin E deprivation is to be found in the paper of Evans and Burr,2 in which is described paralysis of suckling rats born of vitamin E—deficient mothers. No study was made at that time of the underlying pathologic process. Material from such rats, however, was available to Lipschütz,

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