In this communication we report the results obtained from the administration of androgen to 20 male patients who exhibited signs of the involutional psychosis. Testosterone propionate1 was employed. This substance resembles the natural androgen in all respects.
During the first week the patients received 70 to 75 mg. of testosterone propionate, injected intramuscularly. Ten milligrams was administered daily to 15 patients. Five patients had injections of 25 mg. three times weekly. For the next month the patients received 30 to 50 mg. weekly. When sufficient improvement was not obtained, a maintenance dose of 20 to 25 mg. was administered for another month. With 6 patients the dose was again increased from 50 to 75 mg. during the second month. The average duration of treatment was six weeks. Only 1 patient received treatment for more than three months. The progress of 15 of these patients has been followed for more
DAVIDOFF E, GOODSTONE GL. USE OF TESTOSTERONE PROPIONATE IN TREATMENT OF INVOLUTIONAL PSYCHOSIS IN THE MALE. Arch NeurPsych. 1942;48(5):811-817. doi:10.1001/archneurpsyc.1942.02290110131007