The occurrence of local swelling or edema of the cerebral cortex following a lesion is well known. Aside from this localized disturbance, generalized swelling of the brain is occasionally observed in the course of some neurosurgical procedure, such as operation on the pituitary region, and may also be produced experimentally by lesions of the midbrain (Le Beau and Bonvallet1). We have studied this type of experimental swelling of the brain following lesions of the floor of the fourth ventricle and the medulla.
Sixty-six adult dogs were used in this series. All the experiments were carried out with the animals under anesthesia induced with soluble pentobarbital U. S. P. To observe the volume of the brain one or two trephine windows (1 to 1.5 cm. in diameter) were made in the parietal region, and the dura was opened. Craniotomy was made in the region of the posterior fossa to
OBRADOR S, PI-SUÑER J. EXPERIMENTAL SWELLING OF THE BRAIN. Arch NeurPsych. 1943;49(6):826-830. doi:10.1001/archneurpsyc.1943.02290180050005