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August 1943

NEGATIVE THERAPEUTIC EFFECT OF MASSIVE DOSES OF VITAMIN E ON AMYOTROPHIC LATERAL SCLEROSIS

Author Affiliations

Washington, D. C.

From the Department of Anatomy, George Washington University School of Medicine.

Arch NeurPsych. 1943;50(2):190-192. doi:10.1001/archneurpsyc.1943.02290200090008
Abstract

The early favorable reports of investigators1 on the therapeutic use of vitamin E for certain neuromuscular diseases of uncertain origin have not been confirmed by more recent workers.2 A careful survey of the literature on this controversial subject suggested to us that possibly prolonged massive doses of vitamin E (alpha tocopherol)3 might be beneficial in these neuromuscular disorders. Wechsler4 and Spies and Vilter5 administered trial doses of 1,000 and 500 mg. respectively to patients suffering from such disturbances. No apparent harmful effect on these patients was observed. We decided, therefore, to maintain a small series of patients under treatment with prolonged massive doses of alpha tocopherol, averaging as much as 1,000 mg. per day, for varying periods (twenty-three to one hundred and twenty days). Approximately one half of the daily dose was given intramuscularly in sterile peanut oil and the remaining amount was given orally

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