[Skip to Content]
[Skip to Content Landing]
Other
September 1943

GENEALOGIC AND CLINICOPATHOLOGIC STUDY OF PICK'S DISEASE

Author Affiliations

ANN ARBOR, MICH.

From the Neuropsychiatric Institute, University Hospital, University of Michigan.

Arch NeurPsych. 1943;50(3):288-303. doi:10.1001/archneurpsyc.1943.02290210066004
Abstract

Knowledge of the clinical and pathoanatomic features of Pick's disease has been considerably advanced in recent years, but the cause and pathogenesis are still incompletely understood. Some of the early investigators (Gans,1 Reich and Kufs2) suggested that the disease may have a hereditary basis, and this assumption has been borne out by subsequent clinical and genealogic studies (Grünthal,3 Verhaart,4 Schmitz and Meyer,5 Haskovec6 and Löwenberg and others7). In 1930 Grünthal8 made the first pathoanatomic confirmation of this view in a study of 2 brothers, followed by that of von Braunmühl and Leonhard9 in the cases of 2 sisters (1934). Convincing proof was furnished in 1939 by Sanders and others,10 who reported on a family showing evidence of the disease in 17 members, the disorder being transmitted through four generations and its presence being confirmed at autopsy in 4 instances. We

×