The paucity of recorded cases of familial multiple sclerosis verified by necropsy has prompted us to report 2 such cases which we observed at the Montefiore Hospital. Many authors doubt or deny the occurrence of familial multiple sclerosis. "Some of the cases referred to," said Bramwell,1 "have undoubtedly belonged to the category of familial spastic paraplegias." Putnam2 stated:
There are, to be sure, occasional instances in which two cases have occurred in the same family, but they are probably to be ascribed either to coincidence, or to confusion with hereditary ataxia which sometimes closely simulates multiple sclerosis.
The majority of the reported cases have been described only clinically, and in view of the protean character of the disease it seems inadvisable to accept such cases as evidence of proved familial multiple sclerosis. A few cases, however, have been reported with necropsy.
Kramer3 reported the case of a
Spiegel LA, Keschner M. FAMILIAL MULTIPLE SCLEROSIS. Arch NeurPsych. 1943;50(6):706-709. doi:10.1001/archneurpsyc.1943.02290240090009