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April 1944

BIOCHEMICAL ASPECTS OF GLUTAMIC ACID THERAPY FOR EPILEPSY

Author Affiliations

NEW YORK

From the Departments of Neurology and Biochemistry, Columbia University, and the Department of Biochemistry, New York State Psychiatric Institute and Hospital.

Arch NeurPsych. 1944;51(4):393-396. doi:10.1001/archneurpsyc.1944.02290280091005
Abstract

Recently, the use of dl-glutamic acid hydrochloride in the treatment of epileptic patients suffering from seizures of the petit mal and the psychomotor type was described.1 Administration of the racemic amino acid hydrochloride to patients who were resistant to the usual anticonvulsant therapy resulted in a decrease in the frequency of seizures and in an increase in mental and physical alertness. The anticonvulsant therapy, though ineffective previously, was continued through the period of administration of the amino acid hydrochloride. Seizures of the grand mal type were unaffected, or were increased, by this treatment.

It is of primary interest to discover the mechanism through which dl-glutamic acid hydrochloride exercises its effect, and the experiments described in this paper were directed toward this objective.

As was pointed out previously,1 the use of the dl-glutamic acid hydrochloride was suggested (a) by the close relation of the natural, l

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