Knowledge of the presence of characteristic roentgenographic changes in the skull of patients with tuberous sclerosis has been a fairly recent addition to the diagnostic criteria of this disease entity. In 1924 Marcus1 described the roentgenogram in a case of tuberous sclerosis, as follows:
In several places within the cranium were calcified areas the size of a bean or pea, with layers of "chalk shale." Most such areas were located in the middle fossa on the left side, but several were visible in the parietal regions.
Dalsgaard-Nielsen stated that Marcus' case is the first published instance of tuberous sclerosis with roentgenographically discovered calcification in the cerebrum. In 1935 Dalsgaard-Nielsen2 published the following description of the calcifications noted in roentgenograms of the skull of a 14 year old boy with convulsive seizures and adenoma sebaceum.
The shape of the cranium is normal. The sella turcica is small but otherwise
DICKERSON WW. CHARACTERISTIC ROENTGENOGRAPHIC CHANGES ASSOCIATED WITH TUBEROUS SCLEROSIS. Arch NeurPsych. 1945;53(3):199–204. doi:10.1001/archneurpsyc.1945.02300030036005