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May 1945

CEREBRAL INJURY BY BLUNT MECHANICAL TRAUMASPECIAL REFERENCE TO THE EFFECTS OF REPEATED IMPACTS OF MINIMAL INTENSITY; OBSERVATIONS ON EXPERIMENTAL ANIMALS

Author Affiliations

HARDING, MASS.

From the Laboratories of the Medfield State Hospital.

Arch NeurPsych. 1945;53(5):333-354. doi:10.1001/archneurpsyc.1945.02300050007002
Abstract

PURPOSE OF INVESTIGATION  It has been suggested by several investigators that the effects of cerebral trauma may be cumulative. As far back as 1874 Koch and Filene1 had shown that animals could be killed by repeated small blows on the head without showing any evidence of structural damage to the brain. Later Martland2 recognized a peculiar condition occurring among prize fighters, which he named "punch drunk" and which he attributed to the repeated head punishments they had suffered while in the ring. Then Shaller, Tamaki and Newman3 showed the apparent increase in vulnerability of the cerebral vessels induced by the application of repeated blows. More recently Denny-Brown and Russell4 demonstrated that paralysis of respiration of increasing duration and rise of blood pressure occurred with successive blows and that concussion could be obtained readily by repetition of moderately severe blows.In apparent contrast to these observations are

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