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November 1945

EPENDYMITIS AND MENINGITIS DUE TO CANDIDA (MONILIA) ALBICANSREPORT OF A FATAL CASE OF MENINGITIS, WITH COMMENT ON ITS CLINICAL, BACTERIOLOGIC AND PATHOLOGIC ASPECTS

Author Affiliations

MONTREAL, CANADA

From the Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute, and the Department of Bacteriology, McGill University.

Arch NeurPsych. 1945;54(5):361-366. doi:10.1001/archneurpsyc.1945.02300110045006
Abstract

Meningeal involvement due to Candida (Monilia) albicans has been described so rarely that the report of a fatal case of meningitis caused by this organism seems justifiable. In the available literature only 2 previously reported cases with definitely established diagnosis were found, 1 by Smith and Sano1 and 1 by Miale.2 It is questionable whether infections of the central nervous system with Candida albicans are actually as rare as the literature seems to indicate or whether the condition remains undiagnosed in a considerable number of cases because of the difficulties which the classification of the fungi imperfecti present for the bacteriologic laboratory. The latter point seems to be substantiated by the survey of Freeman,3 in which, besides the well established infections with Torula histolytica, Blastomyces and Coccidioides, cases of meningitis due to "Endomyces" and "Saccharomyces" with questionable or no bacteriologic studies are cited. The excellent article by

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