The introduction of penicillin has caused a renewed interest in the treatment of early1 and late2 syphilis. In this paper an account is given of the course of early dementia paralytica in a man aged 31 who at no time was subjected to any other form of therapy. Treatment with penicillin appeared to produce a remission. Psychologic examinations made before and after treatment confirmed the clinical impression of remission and permitted a roughly quantitative estimate of the degree of improvement. Since serologic reversal is often minimal or absent when penicillin alone is used in the treatment of late syphilis, it is suggested that psychologic examinations, repeated at stated intervals, may provide an early indication for repetition of treatment.
The clinical methods used in this study were the standard physical, neurologic and serologic tests and examination of the cerebrospinal fluid. The psychologic methods utilized were the Wechsler-Bellevue Adult Scale
STERN JE, CAMPBELL HM. EARLY EFFECTS OF PENICILLIN TREATMENT OF DEMENTIA PARALYTICAA Clinical and Psychologic Study. Arch NeurPsych. 1946;55(3):266-273. doi:10.1001/archneurpsyc.1946.02300140097006