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May 1947

HISTOPATHOLOGIC CHANGES ASSOCIATED WITH HUMAN POLIOMYELITIS

Author Affiliations

CINCINNATI

From the Laboratory of Neuropathology, Cincinnati General Hospital, and the University of Cincinnati College of Medicine.

Arch NeurPsych. 1947;57(5):565-577. doi:10.1001/archneurpsyc.1947.02300280059003
Abstract

IN SPITE of numerous studies concerning the histopathology of human poliomyelitis, the following problems remain controversial: (1) the localization of the disease and its distribution; (2) the primary type of the essential lesions (whether the alterations in the nerve cells or the inflammatory mesodermal reactions comprise the primary process); (3) the correlation of the neuronal damage and the mesodermal-glial alterations, and (4) the role played by the microglia.

The purpose of this paper is to review some of the conflicting views and to attempt to arrive at an acceptable conclusion concerning some of the aforementioned problems. This presentation is the result of a detailed study of 6 cases of acute anterior poliomyelitis.

Until recently the attention of clinicians and pathologists interested in poliomyelitis was centered almost exclusively on the spinal cord and the medulla. Since 1929, however, when Thomas and Lhermitte3 pointed out that the motor cortex may be

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