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May 1947


Author Affiliations

Fellow in Neurosurgery, Mayo Foundation; ROCHESTER, MINN.

From the Department of Neurosurgery, the Mayo Foundation (Dr. Polmeteer), and the Section on Pathologic Anatomy, the Mayo Clinic (Dr. Kernohan).

Arch NeurPsych. 1947;57(5):593-616. doi:10.1001/archneurpsyc.1947.02300280087005

THE TERM "meningeal gliomatosis" has been adopted for the title of this study to designate involvement of the leptomeninges by tumors of neuroectodermal origin, in contradistinction to those tumors arising from the mesodermal elements. The terms "gliomatous meningitis" and "tumorous meningitis" erroneously imply an infective process, and forthis reason the more descriptive term "meningeal gliomatosis" was chosen.

This study consisted of a review of the gliomas observed at the Mayo Clinic during the period from 1922 to 1942, inclusive, and concerned the finding of metastatic implantations from these gliomas to the leptomeninges of the brain and the spinal cord and the ependyma of the ventricular system. This study was primarily concerned with those gliomas which had established themselves in multiple sites and were responsible for a generalized involvement of the leptomeninges.

Although the earlier literature contains many references to tumors of the central nervous system which had produced local or