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July 1947

NEUROPSYCHIATRIC MANIFESTATIONS DURING THE COURSE OF MALARIAExperiences in the Mediterranean Theater in World War II

Arch NeurPsych. 1947;58(1):14-27. doi:10.1001/archneurpsyc.1947.02300300024003
Abstract

MALARIA is one of the most widespread and prevalent diseases known to man. The armed forces of the United States encountered this infection in its various forms in many parts of the world. Many thousands of the military personnel were treated successfully for tertian, quartan or malignant tertian infection. In unknown thousands the disease was suppressed by the quinacrine (atabrine)—quinine prophylactic regimen, so that to date there has been no clinical evidence of the infection. It may be expected that with return of the troops to the United States cases of malaria will appear in nonendemic zones as well as in endemic areas. This is because those who have had the disease will have recurrences. Nocht and Mayer1 pointed out that tertian malaria may recur up to five years in a nonendemic zone and malignant tertian malaria up to two years, arid that quartan malaria may lie dormant for

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