IT HAS been reported1 that patients with schizophrenia or depression differ from each other in their clinical and psychologic responses to the intravenous administration of subnarcotic doses of sodium amytal followed by amphetamine sulfate N. N. R. One such prominent difference is in the development of tolerance to these drugs in terms of the type and duration of the psychologic response, which developed rapidly in patients with schizophrenia but more slowly in patients with depression.
Since barbiturates inhibit, in vitro, the oxidation of d-glucose, lactate and pyruvate in brain tissue,2 may not the explanation of the differences in the responses of these two groups of patients to sodium amytal lie in differences of oxidation of carbohydrate? Looney3 reported that there is a relatively greater accumulation of unoxidized lactic acid in the blood of schizophrenic patients than in the blood of normal subjects as a response to
FEATHERSTONE RM, CARTER HR, GOTTLIEB JS. PSYCHOPHARMACOLOGIC STUDY OF SCHIZOPHRENIA AND DEPRESSIONSLactic and Pyruvic Acid Content of the Blood Before and After Administration of Sodium Amytal. Arch NeurPsych. 1947;58(2):180-183. doi:10.1001/archneurpsyc.1947.02300310060003