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August 1947

Penicillin in Neurology.

Arch NeurPsych. 1947;58(2):250. doi:10.1001/archneurpsyc.1947.02300310130014

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By presenting the results of their animal and human experimental work on penicillin and integrating their material with the many reports flooding the periodicals in this active and fruitful field, the authors have produced a most useful monograph for all who would utilize penicillin therapy understandingly.

After briefly discussing antibiotics and factors influencing their effective action, the authors present their technic for culturing the offending organism and determining its sensitivity to penicillin, stressing the necessity of this knowledge for proper management. Then are described the experiments which demonstrate the failure of penicillin systemically administered to penetrate the hematoencephalic barrier in the normal brain, while proving its passage in the presence of meningitis. The spinal fluid levels attainable with systemic administration are measured and compared with the concentration needed for therapeutic effect. Since the attainable levels frequently do not suffice, the complemental use of intrathecal, intracisternal and intraventricular injections, and the