EVIDENCE of a vitamin deficiency is usually considered a valid indication for the use of the vitamin as a therapeutic agent. No conclusive evidence of a deficiency of vitamin E has been presented in human beings. Nevertheless, this vitamin has been used in therapeutic tests and favorable results have been reported in cases of habitual abortion,1 premature separation of the placenta,2 chronic nephritis associated with hypertensive vascular disease3 and the menopausal syndrome.4
The advent of more potent, purified preparations has made possible intensification of research in a wider field of clinical application. Christy gave preparations of vitamin E to 25 patients with surgical menopause.
No patient was treated who did not complain of severe symptoms of vasomotor instability. The amount of the drug taken varied from 10 to 30 mg. [of ephynal acetate] a day... over periods of from one to six weeks. Seven patients reported
MICHAEL ST, RUGGLES AH. VITAMIN E IN TREATMENT OF MENTAL DISORDERS. Arch NeurPsych. 1947;58(3):351-356. doi:10.1001/archneurpsyc.1947.02300320102006