PREVIOUSLY we1 reported that the experimental production of epilepsy in the monkey was associated with electroencephalographic abnormality. It was noted that in addition to a primary focus in the region of application of the inciting agent, there was evidence of spread of electroencephalographic abnormality to the opposite side of the brain.2
The present study is concerned with more detailed observations regarding the time relation between electroencephalographic evidence of primary and secondary foci and the onset of convulsive seizures. In addition, the effect of ablation of the "active" focus was investigated.
—In accordance with the method previously described,1a unilateral application of hydrous oxides of aluminum to the motor cortex of 4 monkeys resulted in epileptiform seizures in every instance on physical stimulation. As controls, 3 additional monkeys similarly prepared with noneffective materials at no time manifested convulsive seizures. Electroencephalographic records were taken before operation and
PACELLA BL, KOPELOFF LM, KOPELOFF N. ELECTROENCEPHALOGRAPHIC STUDIES ON INDUCED AND EXCISED EPILEPTOGENIC FOCI IN MONKEYS. Arch NeurPsych. 1947;58(6):693-703. doi:10.1001/archneurpsyc.1947.02300350043003