[Skip to Content]
[Skip to Content Landing]
Other
January 1948

CEREBRAL INVOLVEMENT BY OSTEOGENIC SARCOMA ASSOCIATED WITH PAGET'S DISEASE OF THE SKULL

Author Affiliations

BALTIMORE

From the Department of Pathology, University of Maryland School of Medi

Arch NeurPsych. 1948;59(1):99-106. doi:10.1001/archneurpsyc.1948.02300360109006
Abstract

THE OCCURRENCE of Paget's disease (osteitis deformans) and osteogenic sarcoma is occasionally reported. Involvement of the skull by osteogenic sarcoma, with subsequent cerebral extension, has received little mention in the literature, only 2 cases having been reported. Wolfe and Black1 reported a case with subdural extension and without cerebral involvement. Kirschbaum2 presented the first known case of osteogenic sarcoma (fibrosarcoma) complicating Paget's disease associated with cerebral extension. The case to be reported here is probably the third of its type and perhaps the first to represent an osteolytic form of osteogenic sarcoma.

REPORT OF CASE 

Clinical History.  —K. P., a white woman aged 68, a widow, was first admitted to the University Hospital on Feb. 15, 1942, with a cyst on the left side of her forehead, which had begun to bleed after an attempted local excision by her family physician on Dec. 7, 1941. A microscopic section

×