ERGOT and its derivatives have been in use in the treatment of psychiatric disorders for many years, largely on an empiric basis. The drug had some vogue in the treatment of delirium tremens early in the present century.1 It was noted to be particularly effective in controlling tremor. Beckman,2 however, did not mention this use in the third edition of his book. Ergot has also been prescribed, usually in combination with some form of belladonna and a sedative, in the treatment of "nervousness." Its modern use in the treatment of migraine is referred to in the discussion of the pharmacology to follow.
In 1944 Heath and Powdermaker3 called attention to the effectiveness of ergotamine tartrate U.S.P. in controlling the acute symptoms resulting from exposure to fearful situations and physical depletion. They pointed out that the report was of a preliminary nature, that the number of cases studied
LEMKAU PV, SAMPLINER RB. ERGOTAMINE TARTRATE IN TREATMENT OF COMBAT EXHAUSTION. Arch NeurPsych. 1948;60(1):61-69. doi:10.1001/archneurpsyc.1948.02310010067005