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August 1948

HEMORRHAGIC LESIONS IN THE CENTRAL NERVOUS SYSTEM IN ACUTE POLIOMYELITIS

Author Affiliations

OMAHA

From the Department of Pathology and Bacteriology of the Creighton University Medical School, and the laboratories of the Douglas County and St. Joseph's Hospitals.; Creighton University Medical School.

Arch NeurPsych. 1948;60(2):182-195. doi:10.1001/archneurpsyc.1948.02310020078006
Abstract

IN THE EPIDEMIC of acute poliomyelitis in Nebraska in 1946, we performed autopsies in 14 cases of the bulbar type of this disease. The gross lesions in the central nervous system were unexpected in that there was an unusual amount of hemorrhagic change. This prompted a study of the nature of these hemorrhagic lesions.

METHODS AND MATERIAL  Autopsies were performed two to ten hours post mortem in hot weather. The pathologic observations (except for those in the central nervous system) are given in table 1.

Central Nervous System.—  Fourteen brains and 13 spinal cords were ex- amined. The brains and cords, after initial examination, were suspended in solution of formaldehyde U.S.P. (1:4) for three weeks or longer. The brains were then sectioned coronally and the cords transversely. Sections for histologic study were taken from the frontal, parietal and occipital lobes; basal ganglia; thalamus; midbrain; cerebellum; pons; medulla, and cervical, thoracic

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