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October 1948

THE ELECTROENCEPHALOGRAM OF MULTIPLE SCLEROSISReview of the Literature and Analysis of Thirty-Four Cases

Author Affiliations


From the Department of Neurology, University of Michigan and University Hospital, Ann Arbor, Mich.

Arch NeurPsych. 1948;60(4):376-387. doi:10.1001/archneurpsyc.1948.02310040047004

MULTIPLE sclerosis, according to Grinker,1 ranks third in frequency among neurologic disorders. Its incidence varies somewhat with geographic location, and apparently with other factors, for Wilson2 stated that between 1908 and 1925 at the National Hospital it actually ranked first (multiple sclerosis, 1,398 cases; intracranial tumor, 1,352 cases; neurosyphilis, 1,340 cases), while the average occurrence in England and Wales over a long period was second only to that of neurosyphilis. In Switzerland2 the disease is said to be twice as frequent as in England. Neilsen3 stated that the disease has become much more frequent in the United States in the past fifteen years. Camp4 has seen approximately 2,500 clinic cases and 700 private cases in the past forty years. In the University of Michigan Hospital the diagnosis of multiple sclerosis was made in 485 cases in the five year period ending March 31, 1947.