MORE or less as the result of chance, bromides1 and barbiturates2 became known as useful drugs in the control of seizures. Good results in the treatment of patients with convulsive seizures were obtained with these two drugs and with fasting,3 ketogenic4 diet and dehydration.5 However, there still remained a great number of patients who were not so benefited. Surgery and psychotherapy added to the number of patients whose seizures were brought under control.
In 1937, Putnam and Merritt6 devised an experimental procedure which resulted in a striking acceleration in the development of additional drugs for use in the control of epileptic seizures. Their clinical report,7 which followed shortly their laboratory studies, stimulated what later proved to be a justified enthusiasm for the use of diphenylhydantoin sodium U.S.P. (dilantin®). With the interest in this new drug went an intensive search for other drugs
RUSKIN DB. MESANTOINR (METHYLPHENYLETHYL HYDANTOIN) IN TREATMENT OF EPILEPSY IN A STATE HOSPITAL. Arch NeurPsych. 1948;60(5):484-497. doi:10.1001/archneurpsyc.1948.02310050061005