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February 1949

TETRAETHYLAMMONIUM CHLORIDE IN TREATMENT OF HERPES ZOSTER AND INTERCOSTAL NEURALGIA

Author Affiliations

DETROIT

From the Departments of Internal Medicine and Surgery, Riverside Clinic.

Arch NeurPsych. 1949;61(2):194-198. doi:10.1001/archneurpsyc.1949.02310080098009
Abstract

THE TETRAETHYLAMMONIUM ion1 has been established as an effective therapeutic agent in the treatment of herpes zoster and related painful conditions. Tetraethylammonium is a quarternary ammonium ion, the chloride compound of which has a structure similar to that of acetylcholine. The chief effect of the tetraethylammonium ion has been its ability to produce a block of the autonomic ganglia.2

Findley and Patzer3 reported 4 cases of herpes zoster treated successfully by paravertebral procaine block. An acute inflammation of the dorsal spinal ganglia with degenerative changes in the corresponding sensory nerves, posterior horn cells and dorsal roots has been demonstrated in this disease.4 Bielschowsky5 has found minor inflammatory changes in the sympathetic chain at the time of an attack of herpes zoster. Vasospasm, which is a contributory factor in herpes zoster, was relieved by block of the autonomic ganglia.3 After paravertebral procaine block, there occurs

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