TWO OPPOSING views are held regarding the clinical manifestations of the pathologic changes in the nervous system that result from vitamin A deficiency. One group of investigators1 observed weakness, incoordination and ataxia in their experimental animals, and they demonstrated lesions in the brain, spinal cord and peripheral nerves. A second group2 found no significant clinical or pathologic changes in their vitamin A-deficient animals. There was a difference of opinion among the former group as to the mechanism of formation of the pathologic changes. Mellanby1c expressed the opinion that the degenerative changes in the central nervous system and peripheral nerves are specific for avitaminosis A, whereas Wolbach and Bessey3 stated the belief that the lesions result from a mechanical distortion produced by the differential rate of growth between the spinal cord and the vertebral column.
Recently, in a study in this laboratory of malaria in ducks fed
FLETCHER DE, RIGDON RH. NEUROLOGIC MANIFESTATIONS ASSOCIATED WITH VITAMIN A DEFICIENCY IN YOUNG DUCKSA Clinical and Pathologic Study. Arch NeurPsych. 1949;61(2):199–209. doi:10.1001/archneurpsyc.1949.02310080103010