IN THE first half of 1948 I observed 3 cases in which diagnostic Mantoux tests were followed by symptoms and signs of a lesion of the central nervous system. Local and general reactions to the Mantoux test appeared in these cases comparatively early, within six to twenty-four hours, while the neurologic illness followed within a few days in 2 cases and within several weeks in 1 case. The clinical picture corresponded in all cases to that of disseminated leukoencephalomyelitis (multiple sclerosis).
It is known that a leukoencephalomyelitic process may occur as a complication of extraneural infectious diseases and vaccinations. Observations of this kind were cited by Pette1 to support the theory of the allergic origin of disseminated leukoencephalomyelitis.
Since I could find in the literature no data on neurologic complications of the Mantoux inoculation, my 3 cases will be recorded in some detail.
REPORT OF CASES
MÉREI FT. NEUROLOGIC COMPLICATIONS FOLLOWING THE MANTOUX TEST. Arch NeurPsych. 1950;63(2):249-256. doi:10.1001/archneurpsyc.1950.02310200057006