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May 1950

SECTION OF CORPUS CALLOSUM IN EXPERIMENTAL EPILEPSY IN THE MONKEY

Author Affiliations

NEW YORK

Now at the Department of Surgery, University of Oregon Medical School, Portland, Ore.

From the Department of Bacteriology, New York State Psychiatric Institute and Hospital; the Departments of Anatomy and Psychiatry, New York University Medical School, and the Neurological Division of St. Vincent's Hospital.

Arch NeurPsych. 1950;63(5):719-727. doi:10.1001/archneurpsyc.1950.02310230041003
Abstract

THE EFFECT of section of the corpus callosum on human epilepsy remains a controversial issue. Van Wagenen and Herren1 found that in patients with generalized convulsions section of commissural pathways contained in the corpus callosum limited the spread in a unilateral convulsion with no loss of consciousness. Erickson,2 using electrical stimuli, showed that in the monkey section of the corpus callosum played a definite role in the spread of a discharge from one hemisphere to the other. Curtis3 concluded that the typical response to the application of a convulsant drug in monkeys and cats was mediated by the corpus callosum and abolished by its section. Obrador Alcalde,4 studying convulsive attacks produced by electrical stimulation of the cortex in cats, reported that section of the corpus callosum did not change the fundamental character of the convulsions and concluded that the corpus callosum was not an association system

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