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February 1951

ENCEPHALITIC FORM OF METASTATIC CARCINOMA

Author Affiliations

PHILADELPHIA

From the Department of Neurology, Jefferson Medical College of Philadelphia.

AMA Arch NeurPsych. 1951;65(2):161-173. doi:10.1001/archneurpsyc.1951.02320020033003
Abstract

CARCINOMATOUS extension to the nervous system manifests itself in many fashions. Among these are solitary metastasis to the brain and multiple metastases of varying number and size. Less common, and not sufficiently recognized for either its pathological or its clinical features, is the encephalitic form of carcinomatous metastasis, which may closely simulate encephalitis of other types. It is to call attention to this form of metastatic carcinoma that the following cases are reported.

REPORT OF CASES 

Case 1.  —J. A. (N.P. 42-154). Bronchiogenic carcinoma in a man aged 55, with an organic mental syndrome; later appearance of hemiparesis, aphasia, cerebellar signs and convulsive movements. Diffuse carcinomatous infiltration of the meninges, brain, brain stem, cerebellum and spinal cord.

History.  —A white man aged 55 was first seen by one of us (B. J. A.) on July 26, 1942, at which time he stated that he was not as fit generally as

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