IN 1947 a series of operations designated as "topectomies" were performed on a group of chronic schizophrenic patients at the New Jersey State Hospital, at Greystone Park. Since the studies of these patients were undertaken by both the hospital staff and members of Columbia University College of Physicians and Surgeons, the work became known as the Columbia-Greystone I Project. The numerical designation was necessary, since two subsequent investigations were carried out by essentially the same group of associates.
The topectomies consisted of selective partial ablations of the frontal lobe and have been reported in full detail.1 Various Brodmann areas were removed, and there was a strong impression that extirpation of Brodmann areas 8, 9, 10 and/or 46 were distinctly beneficial, in contrast to removal of certain other areas (6, 11, 24, 44, 45 and 47).
A portion of the patients did not have topectomies but served as controls. Subsequently,
KLINE NS, TENNEY AM. PROGNOSIS IN TOPECTOMIES AND LOBOTOMIES RELATIVE TO BODY TYPE. AMA Arch NeurPsych. 1951;65(3):323-325. doi:10.1001/archneurpsyc.1951.02320030060006