THE PURPOSE of this paper is to put on record the observations on capillaroscopic changes in multiple sclerosis and various neuropsychiatric disorders. A number of articles on the alterations in the capillaries in thromboangiitis obliterans,1 Raynaud's disease,2 epilepsy,3 migraine,4 neurosis,3b nerve injuries, acrocyanosis and hemiplegia,6 schizophrenia and manic-depressive psychosis,7 and other mental diseases8 have been published. Besides the publications of Benedict9 and Brickner and Franklin,10 who emphasized spasmodic obliteration of retinal circulation, there exist only two papers, those by Gomirato11 and by Chiavacci and Putnam,12 on capillaroscopic observations in multiple sclerosis. The authors of these two papers have studied the capillaroscopic changes in cases of multiple sclerosis, and the incidences of abnormality are closely comparable in the two series.
Chiavacci and Putnam12 observed definite alteration in the capillaries, consisting mainly in spasticity, sluggishness or absence of circulation,
MUTLU N. CAPILLAROSCOPIC STUDIES IN CASES OF MULTIPLE SCLEROSIS AND OTHER NEUROPSYCHIATRIC DISORDERS. AMA Arch NeurPsych. 1951;66(3):363-367. doi:10.1001/archneurpsyc.1951.02320090112010