LITTLE information regarding the importance of the age of onset to the course and prognosis of disseminated sclerosis is found in the literature. Any such information is usually expressed in general terms and is not substantiated by an account of series studied. Thus, statements regarding the course of the disease have been made by Laignel-Lavastine and Koressios,1 Pette,2 and Brain,3 among others. They expressed the opinion that the disease often has a progressive course when the onset takes place at a more advanced age. Beringer4 did not agree with this view.
The series reported are not sufficiently large to permit statistical analyses, and the data regarding their composition are often incomplete. McAlpine5 made a follow-up study of 142 patients and found that the course of the disease was usually progressive when the patient was in a higher-age group at the onset. In an autopsy material,
MÜLLER R. COURSE AND PROGNOSIS OF DISSEMINATED SCLEROSIS IN RELATION TO AGE OF ONSET. AMA Arch NeurPsych. 1951;66(5):561-570. doi:10.1001/archneurpsyc.1951.02320110026002