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April 1952

RIBOSURIAA Clinical Test for Muscular Dystrophy

Author Affiliations

NASHVILLE, TENN.

From the Departments of Psychiatry and Biochemistry, Vanderbilt University School of Medicine.

AMA Arch NeurPsych. 1952;67(4):483-486. doi:10.1001/archneurpsyc.1952.02320160067007
Abstract

THERE has always been difficulty in differentiating and in classifying the various diseases in which motor weakness and muscular wasting are the prime symptoms. The seemingly endless variations and gradations of types have led many investigators to combine groups of them under the general heading of heredodegenerative disease, rather than pursue the fruitless task of making a specific diagnosis. This is reasonable, as, with two notable exceptions, no specific treatment has proved effective and the diagnosis is often nothing more than a glossary of eminent neurologists of the past.

Laboratory tests, including determinations of electrical reactions, creatine excretion, and tolerance, have occasionally proved helpful but are not specific for one group as opposed to another. Muscle biopsy is often inconclusive. Even necropsy may leave the diagnosis in doubt.

In a study of urine in several cases of pseudohypertrophic muscular dystrophy, Minot1 noted that reduction was invariably obtained when 8

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