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April 1952

EFFECT OF EPINEPHRINE ON CORTICAL AND BASAL ELECTROENCEPHALOGRAMS AND THE EOSINOPHILE COUNT

Author Affiliations

With the Technical Assistance of Shirley Goldman, A.B. CHICAGO

From the Institute for Psychosomatic and Psychiatric Research and Training, Michael Reese Hospital, Chicago, and the National Institute of Mental Health, United States Public Health Service, Bethesda, Md.

AMA Arch NeurPsych. 1952;67(4):522-534. doi:10.1001/archneurpsyc.1952.02320160106011
Abstract

THE PURPOSE of this study was to examine the cortical and basal electroencephalograms of subjects without clinical epilepsy or pituitary-adrenocortical disease who receive injections of epinephrine ordinarily sufficient to stimulate the secretion of adrenocortical hormone, as judged from the change in the absolute eosinophile count. These observations should indicate whether or not there is any relevant electroencephalographic activity, cortical or diencephalic, concomitant with adrenergic stimulation of the pituitary-adrenocortical system. Such information, it was hoped, might be helpful in determining what, if any, modifying influences the cortex and diencephalon have upon adrenocorticotrophic activity.

A search of the literature to find what effects of epinephrine on cerebral electrical activity might be expected indicates lack of agreement and unformity on the subject. Some authors report no appreciable effects of epinephrine on the electrogram1 or electroencephalogram.2 Others report definite effects on the cortical and basal electroencephalograms.3 Some of these variations may

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